The closely related rare and severe acute myeloid leukemias carrying EVI1 or PRDM16 rearrangements share singular biological features

The closely related rare and severe acute myeloid leukemias carrying EVI1 or PRDM16 rearrangements share singular biological features.

In a recent issue of Haematologica, Matsuo et al. pinpoint the pejorative effect of EVI1 overexpression in 18 acute myeloid leukemias (AML) with MLL rearrangements. However, EVI1 overexpression has also been reported in patients with translocations involving chromosome 3 and the EVI1 gene. Because of the poor prognosis associated to these anomalies, it is important to investigate them at an ear...

Therapy-Related Acute Myeloid Leukemias

Therapy-related acute myeloid leukemia (t-AML) is a heterogeneous group of myeloid neo‐ plasms occurring as an overwhelming complication in patients receiving previous cytotoxic chemotherapy and/or radiation therapy used to treat haematopoietic or solid malignancies or associated with immunosuppressive treatment for non-neoplastic rheumatologic/autoim‐ mune diseases or solid organ transplantati...

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations.

The genetic and transcriptional signature of EVI1 (ecotropic viral integration site 1)-rearranged (EVI1-r) acute myeloid leukemias (AMLs) remains poorly defined. We performed RNA sequencing of 12 EVI1-r AMLs and compared the results with those of other AML subtypes (n = 139) and normal CD34(+) cells (n = 17). Results confirm high frequencies of RAS and other activated signaling mutations (10/12...

Classification of acute myeloid leukemias

Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16).

A prenatal origin of translocations associated with pediatric leukemia has been demonstrated for MLL-AF41 in infant leukemia, TEL-AML12,3 in common acute lymphocytic leukemia (cALL), and AML1-ETO4 in acute myeloid leukemia (AML). We investigated whether AML-associated translocations PML-RARA and CBFB-MYHII could arise before birth. PML-RARA arises from the t(15;17) translocation,5 characteristi...